Battery F left the state for Kentucky on March 3, 1862. After months of service in Kentucky, the battery marched across the Cumberland Mountains to Knoxville, Tennessee, in January 1864. In May 1864, Battery F joined William T. Sherman’s Atlanta campaign. It fought at Resaca and Keenesaw Mountain. 

On July 21, 1864, Battery F was credited with being the first Union battery to throw shells into the Confederate stronghold of Atlanta. After the fall of Atlanta, Battery F was sent back to Chattanooga, Tennessee, where it remained until being posted to Nashville, Tennessee. Following the mid-December Battle of Nashville, Battery F was sent to North Carolina where it ended the war. It returned to Jackson, Michigan, where it was mustered out of federal service on July 1, 1865.